With the roots blower:
Get big honkin' bumpsticks with a split duration, approx 15deg more on the exhaust side Install them on a 114deg lobe separation.
Get the long tube header, or at least have a competent fabricator take your shorty and turn it into a step tube header. approx. 26"-30" total length primary (4-1 is okay).
Get the CNC ported head from GMPP catalog.
Pully the hell out ouf it. find out what the max rated rotor speed is for the blower and run it there. You might need a bigger blower to get the lbs/min your looking for across the motor.
Every mod that you do to improve the VE of the motor has a corresponding drop in manifold pressure for a given blower ratio. More of the air is making it into the combustion chamber.
A nice way to go when you get to the bigboy blowers (I like lyscholm screws myself) is 8mm htd drive. It requires profoundly less belt tension,which your front main bearing will thank you for, is quiet and will not slip. They can be sourced from all kinds of places, get a good damper (a must anyway) from ATI and they can probably built one with a cogdrive for you. The rest of the stuff Id buy from jones racing products.
Roots blowers do have there merits. Like what was said above they are linear pumps (well nearly) and make a engine behave as though it were a much larger NA version.
Also liek what was said above you cant turn a blower guy into a turbo guy, or visa versa. My old man is a dyed in the wool hardcore 6-71Gmc and up loving roots blower guy. Ive proven to him time and time again tha tyou dont have to work as hard for the power with a properly sized turbosetup. His response? I DONT CARE! lol.